Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.
Irinotecan is a topoisomerase-I (Top-I) inhibitor used for the treatment of colorectal cancer. DNA demethylating agents, including 5-azacytidine (5-aza), display synergistic antitumor activity with several chemotherapy drugs. 5-Aza may enhance irinotecan cytotoxicity by at least one of the following mechanisms: (a) Top-I promoter demethylation, (b) activation of genes involved in Top-I transcri...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2009
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-09-0027